In brief this study, co-authored by the members of project B05 - David Stahl and Roland Ullrich, identifies a CSF1R⁺ myeloid-monocytic population in primary human B-NHL that suppresses CAR-T cell activity. CSF1R blockade reprograms the tumour microenvironment and boosts CAR-T efficacy in an autochthonous mouse model — supporting further clinical exploration. This excellent work is a strong collaborative effort within the SFB 1530 | CRC 1530 and beyond.
Read the whole article:
Stahl, D., et al. & Ullrich, R.T. CSF1R⁺ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma. Cancer Cell 43, 1-19 (2025). https://doi.org/10.1016/j.ccell.2025.05.013
