Contact information
Department of Translational Genomics
University of Cologne
Weyertal 115b
50931 Cologne
CV
Academic education
| 2003 - 2007 | PhD-program, Max Planck Institute for Plant Breeding Research, Cologne, Germany |
| 1997 - 2002 | MSc in Plant Biotechnology, University of Naples Federico II, Italy |
Scientific degrees
| 2007 | PhD, Supervisor: Dr. Zsuzsanna Schwarz Sommer, Max Planck Institute for Plant Breeding Research, Cologne, GermanyHabilitation, Medical Faculty, University of Cologne, Germany |
Scientific career
| 2023 - present | Project Leader, CRC-1399, project B09, University of Cologne, Germany |
| 2022 - present | Group Leader, Dynamics of mutational processes in cancer, Department of Translational Genomics, University Hospital of Cologne, Germany |
| 2015 - 2022 | Research Scientist, Department of Translational Genomics, University Hospital of Cologne, Germany, Division: Computational Cancer Genomics Group |
| 2014 - 2015 | Research Scientist, Max Planck Plant Breeding Research, Cologne, Germany |
Honors/ Awards/ Memberships
| Member of the CRC 1399 Management Board |
Publications
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LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1
Microenvironmental bystander cells are essential for the progression of chronic lymphocytic leukemia (CLL). We have discovered previously that LYN kinase promotes the formation of a microenvironmental niche for CLL. Here we provide mechanistic evidence that LYN regulates the polarization of stromal…
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CaMuS: simultaneous fitting and de novo imputation of cancer mutational signature
The identification of the mutational processes operating in tumour cells has implications for cancer diagnosis and therapy. These processes leave mutational patterns on the cancer genomes, which are referred to as mutational signatures. Recently, 81 mutational signatures have been inferred using…
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Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy
Pleomorphic dermal sarcoma (PDS) is a rare malignant cutaneous tumor with an unknown cell of origin. Locally defined tumors can be treated by curative excisions, whereas advanced stages of the disease are difficult to treat, using standard regimens. We performed whole-exome sequencing on a cohort…