Contact information
CECAD Research Center
University of Cologne
Joseph-Stelzmann-Straße 26
50931 Cologne
CV
Academic education
| 1987 - 1992 | Undergraduate Studies in Biology, diploma degree, thesis supervisor Dr. George Kollias, University of Athens, Greece |
Scientific degrees
| 1997 | PhD in Biology, supervisor Dr. George Kollias, Awarded by the University of Athens, Greece |
Scientific career
| 2020 - present | Speaker, CRC-1403 on “Cell Death in Immunity, Inflammation and Disease”, University of Cologne, Germany |
| 2023 - 2024 | Senior Visiting Scholar, Genentech Inc., South San Francisco, USA |
| 2009 - 2016 | Member of the Committee for Good Scientific Practice, University of Cologne, Germany |
| 2008 - 2023 | Member of the Academic Advisory Board, University of Cologne, Germany |
| 2008 | Advisory Board, Department for Molecular Biomedical Research, VIB, Gent, Belgium |
| 2007 - 2024 | Executive Board Member and Research Area Leader, Excellence Cluster CECAD |
| 2005 - present | Professor (W3), Institute for Genetics, University of Cologne, Germany |
| 2002 - 2005 | Independent Group Leader, EMBL Mouse Biology Unit, Monterotondo (Rome), Italy |
| 1997 - 2001 | Postdoc, Institute for Genetics (with K. Rajewsky), University of Cologne, Germany |
Honors/ Awards/ Memberships
| 2021 | Organizer, 18th International TNF Conference |
| 2019 | Organizer, EMBO Workshop on “Cell death in immunity and inflammation” |
| 2019 | Organizer, Keystone Symposium on “Immune, Epithelial and Microbiome Crosstalk in Skin Health and Disease” |
| 2017 | Member, Committee for the selection of the director of the Institute of Molecular Biology and Biotechnology (IMBB), University of Crete, Greece |
| 2012 - 2014 | Chair, LS4 Review Panel for ERC Consolidator Grants |
| 2011 - present | Editorial Board, EMBO Molecular Medicine |
| 2010 | Organizer, Keystone Symposium “NF-kappaB in Disease” |
| 2009 - 2012 | Member, LS4 Review Panel for ERC Starting Grants |
| 2009 - 2012 | Editorial Board, European Journal of Immunology |
| 2005 | Chair, External evaluation board, Department for Molecular Biomedical Research, VIB, Gent, Belgium |
Publications
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Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
Caspase-8 is the initiator caspase of extrinsic apoptosis1,2 and inhibits necroptosis mediated by RIPK3 and MLKL. Accordingly, caspase-8 deficiency in mice causes embryonic lethality3, which can be rescued by deletion of either Ripk3 or Mlkl4,5,6. Here we show that the expression of enzymatically…
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Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth
The vasculature represents a highly plastic compartment, capable of switching from a quiescent to an active proliferative state during angiogenesis. Metabolic reprogramming in endothelial cells (ECs) thereby is crucial to cover the increasing cellular energy demand under growth conditions. Here we…