The activation or restoration of immune cells in the tumor microenvironment is an efficient weapon to improve the prognosis of cancer patients. Although B cell lymphoma patients benefit to some extent from T cell-based immunotherapies, the specific needs of these patients suffering from malignant antigen-presenting B cells, naturally specialized for T cell interaction, are unclear. Thus, we will perform holistic analyses of immune response mechanisms and their abrogation during lymphoma development using autochthonous mouse models of aggressive B cell lymphomas.
PRINCIPAL INVESTIGATOR
Project Interactions
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A01
Using autochthonous mouse models of aggressive lymphoma to systematically distill actionable vulnerabilities
Prof. Dr. med. Hans Christian Reinhardt -
A04
Role of apoptotic caspases in lymphomagenesis
Prof. Dr. rer. nat. Hamid Kashkar -
B03
The role of ferroptosis in diffuse large B-cell lymphoma subtypes
Prof. Dr. rer. nat. Silvia von Karstedt -
B05
New strategies to improve the efficiency and safety of CAR-T cells for the treatment of B cell lymphoma
Dr. rer. nat. Markus Chmielewski, Prof. Dr. med. Dr. nat. med. Roland Ullrich -
C05
Characterization of Richter-transformed lymphoma and genomic instability as a potential vulnerability in 17p-deleted lymphomas
Prof. Dr. med. Björn Chapuy, Prof. Dr. med. Barbara Eichhorst