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B04

T cell-based mechanisms of immune evasion in aggressive B cell lymphomas

The activation or restoration of immune cells in the tumor microenvironment is an efficient weapon to improve the prognosis of cancer patients. Although B cell lymphoma patients benefit to some extent from T cell-based immunotherapies, the specific needs of these patients suffering from malignant antigen-presenting B cells, naturally specialized for T cell interaction, are unclear. Thus, we will perform holistic analyses of immune response mechanisms and their abrogation during lymphoma development using autochthonous mouse models of aggressive B cell lymphomas.

PRINCIPAL INVESTIGATOR

Prof. Dr. med. Dr. rer. nat. Sandrine Sander

Adaptive Immunity and Lymphoma

German Cancer Research Center (DKFZ)

Im Neuenheimer Feld 280

69120 Heidelberg

 

National Center for Tumor Diseases (NCT) Heidelberg

Im Neuenheimer Feld 460

69120 Heidelberg