Hodgkin lymphoma is a unique B cell lymphoma regarding the phenotypic heterogeneity of the Hodgkin and Reed-Sternberg (HRS) lymphoma cells, the extent of chromosomal abnormalities, and the occurrence of bi-/multinucleated lymphoma cells. We plan an in-depth analysis of the transcriptomic and epigenetic heterogeneity of single HRS cells, as well as of the genetic heterogeneity and instability of these cells. Furthermore, we plan to uncover the mechanisms causing the generation of bi-/multinuclear lymphoma cells. A comparative analysis of diffuse large B cell lymphomas will uncover common and distinct mechanisms of genetic instability and tumor heterogeneity in these lymphomas.
PRINCIPAL INVESTIGATOR
Institute for Cell-Biology (Oncological Research)
University Hospital Essen
Virchowstraße 173
45122 Essen
Project Interactions
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A01
Using autochthonous mouse models of aggressive lymphoma to systematically distill actionable vulnerabilities
Prof. Dr. med. Hans Christian Reinhardt -
C02
Harnessing defective DNA repair for the treatment of mantle cell lymphoma
Dr. med. Ron Jachimowicz -
C04
Modeling the clonal evolution of high-risk CLL
Prof. Dr. rer. nat. Martin Peifer, Dr. med. Kirsten Fischer -
C05
Characterization of Richter-transformed lymphoma and genomic instability as a potential vulnerability in 17p-deleted lymphomas
Prof. Dr. med. Björn Chapuy, Prof. Dr. med. Barbara Eichhorst