Harnessing defective DNA repair for the treatment of mantle cell lymphoma

B cell development is dependent on functional DNA repair and thus deficiencies within these pathways promote lymphomagenesis and are frequently found in high-risk B cell lymphomas. In this project, mantle cell lymphoma (MCL) will serve as a blueprint, as alterations in key DNA repair pathways are typically present in up to 50% of cases without being therapeutically exploited to date. We will perform functional and longitudinal profiling of genome instability in a high-risk relapse/refractory MCL cohort and mechanistically dissect the kinase-driven DNA repair pathways in order to identify and validate vulnerabilities of rewired DNA repair signaling.


Dr. med. Ron Jachimowicz

Department I of Internal Medicine

University Hospital of Cologne

Kerpener Straße 62 

50937 Cologne


Max Planck Institute for Biology of Ageing

Joseph-Stelzmann-Strasse 9b

50931 Cologne