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C05

Characterization of Richter-transformed lymphoma and genomic instability as a potential vulnerability in 17p-deleted lymphomas

Here, we focus on two distinct diffuse large B-cell lymphoma (DLBCL) subtypes with poor prognosis, DLBCLs with biallelic TP53 inactivation and DLBCLs that arise through Richter transformation (RT) from chronic lymphocytic leukemia (CLL). By applying an integrative multi-omics and multi-platform approach we will characterize the molecular landscape of RT DLBCLs and define cell-autonomous and non-cell-autonomous oncogenic determinants and associated survival pathways of both lymphomas. Longitudinal assessment of alterations in CLL and paired RT-DLBCLs and an in vivo insertional mutagenesis screen will provide mechanistic insights into the molecular basis of RT that will guide our modelling and future targeting strategies.

PRINCIPAL INVESTIGATOR

Prof. Dr. med. Björn Chapuy

Department of Hematology, Oncology and Tumorimmunology
Charité Universitätsmedizin Berlin
Campus Benjamin Franklin
Hindenburgdamm 30
12203 Berlin

 

Prof. Dr. med. Barbara Eichhorst

German CLL Study Group

Department I of Internal Medicine

University Hospital of Cologne

Kerpener Straße 62 

50937 Cologne

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