Apoptosis resistance represents one of the keys giving rise to the pathogenesis of B-cell lymphoma. Caspases have been primarily considered as engines of apoptosis. However, accumulating evidence indicated that caspases are versatile molecular switches that control B-cell proliferation, inflammatory signaling, and differentiation. This project will provide in-depth molecular knowledge about the physiological roles of caspases in B-cell malignancies. The knowledge obtained will be exploited to better understand the pathogenesis of B-cell lymphoma and, in particular, will provide basis for the development of novel therapeutic strategies against B-cell malignancies.
PRINCIPAL INVESTIGATOR
Institute for Molecular Immunology
TRIO Research Center
Joseph-Stelzmann-Straße 26
50931 Cologne
Project Interactions
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A01
Using autochthonous mouse models of aggressive lymphoma to systematically distill actionable vulnerabilities
Prof. Dr. med. Hans Christian Reinhardt -
A02
The functional role of cytoskeletal dysregulation in activated B cell-like diffuse large B cell lymphoma
Prof. Dr. med. Thomas Oellerich -
A06
Understanding resistance towards venetoclax in lymphoma: physiology of genetic alterations in BTG1 and BCL2
Prof. Dr. rer. nat. Ana García-Sáez, Dr. med. Lukas Frenzel -
B01
LYN kinase as a key regulator in the microenvironmental niche of B cell lymphoid tumors
Prof. Dr. med. Michael Hallek, Dr. rer. nat. Phuong-Hien Nguyen -
C05
Characterization of Richter-transformed lymphoma and genomic instability as a potential vulnerability in 17p-deleted lymphomas
Prof. Dr. med. Björn Chapuy, Prof. Dr. med. Barbara Eichhorst