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A04

Role of apoptotic caspases in lymphomagenesis

Apoptosis resistance represents one of the keys giving rise to the pathogenesis of B-cell lymphoma. Caspases have been primarily considered as engines of apoptosis. However, accumulating evidence indicated that caspases are versatile molecular switches that control B-cell proliferation, inflammatory signaling, and differentiation. This project will provide in-depth molecular knowledge about the physiological roles of caspases in B-cell malignancies. The knowledge obtained will be exploited to better understand the pathogenesis of B-cell lymphoma and, in particular, will provide basis for the development of novel therapeutic strategies against B-cell malignancies.

PRINCIPAL INVESTIGATOR

Prof. Dr. rer. nat. Hamid Kashkar

Institute for Molecular Immunology

CECAD - Cluster of Excellence at the University of Cologne

Joseph-Stelzmann-Straße 26

50931 Cologne