LYN kinase as a key regulator in the microenvironmental niche of B cell lymphoid tumors

Based on our discovery that expression of Lyn kinase is required to maintain the leukemia-supporting capacity of both hematopoietic and non-hematopoietic cells in the tumor microenvironment (TME), the central hypothesis of this project is that protein kinases are crucial for the formation of a pro-neoplastic microenvironment in B cell lymphoma. Our work programs combine state-of-the-art genetic modification techniques and integrative analysis of multi-omics data in an array of well-established in vitro and in vivo models to validate the mechanistic actions and regulatory network of Lyn kinase in the lymphoid TME. We will also identify novel targets influencing the tumor-supporting capacity of different TME cells.