Temporal and spatial elucidation of NF- κB signaling in B cell lymphomagenesis

This project studies the role of abnormal NF-κB activation in B cell lymphomas, focusing on its contribution to malignant transformation, therapy resistance, and disease progression. The aim is to determine whether lymphoma cells remain addicted to continuous NF-κB activity and how it influences tumor growth and the microenvironment. Using advanced preclinical models and genetic mouse models, the project will identify critical moments and locations where NF-κB is essential. The goal is to uncover molecular targets for intervention, potentially advancing the therapeutic use of NF-κB inhibitors and improving treatment options.