Ferroptosis is an iron-dependent form of regulated necrosis, resulting from the collapse of cellular antioxidant defense systems. Recently, it was shown that ferroptosis represents an exquisite vulnerability in diffuse large B cell lymphoma (DLBCL) in direct comparison to other cancer entities. Therefore, this project will provide an in-depth characterization of the in vivo role of ferroptosis induction in high-risk DLBCL and mechanistic underpinnings important for efficacy. Insights obtained will be used towards providing rationale for clinical repurposing of compounds inducing ferroptotic cell death for the treatment of high-risk DLBCL.
PRINCIPAL INVESTIGATOR
Department of Translational Genomics
CECAD - Cluster of Excellence at the University of Cologne
Joseph-Stelzmann-Straße 26
50931 Cologne
Project Interactions
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A01
Using autochthonous mouse models of aggressive lymphoma to systematically distill actionable vulnerabilities
Prof. Dr. med. Hans Christian Reinhardt -
A06
Understanding resistance towards venetoclax in lymphoma: physiology of genetic alterations in BTG1 and BCL2
Prof. Dr. rer. nat. Ana García-Sáez, Dr. med. Lukas Frenzel -
B01
LYN kinase as a key regulator in the microenvironmental niche of B cell lymphoid tumors
Prof. Dr. med. Michael Hallek, Dr. rer. nat. Phuong-Hien Nguyen -
B04
T cell-based mechanisms of immune evasion in aggressive B cell lymphomas
Prof. Dr. med. Dr. rer. nat. Sandrine Sander -
C05
Characterization of Richter-transformed lymphoma and genomic instability as a potential vulnerability in 17p-deleted lymphomas
Prof. Dr. med. Björn Chapuy, Prof. Dr. med. Barbara Eichhorst