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Contact information

Dr. rer. nat. Nima Abedpour
Dr. rer. nat. Nima Abedpour

Department of Translational Genomics

TRIO Research Center

University of Cologne

Robert-Koch-Straße 21

50931 Cologne

CV

Academic education

2004 - 2009 PhD, Physics - Complex Systems, Sharif University of Technology, Tehran
2003 - 2004 MSc, Physics - Transferred to PhD, Sharif University of Technology, Tehran
1999 - 2003 BSc, Physics - Iran University of Science and Technology, Tehran
   

Scientific degrees

11/2009                        PhD, Physics - Complex Systems, Sharif University of Technology, Tehran (Supervisors: Prof. M. R. Rahimitabar)

 

Scientific career

2016 - present Postdoctoral Fellow, Computational Cancer Genomics,
University of Cologne
2011 - 2016 Postdoctoral Fellow, Mathematical Modeling of Biological Systems,
Heinrich Heine University, Düsseldorf
2009 - 2011 Postdoctoral Fellow, Institute for Research in Fundamental Sciences
(IPM), Tehran

 

Honors/ Awards/ Memberships

2012 - 2014     EMBO Long-Term Fellowship, 2011, European Molecular Biology Organization
2003 Ranked 32th amongst nearly 6000 participants in the University Entrance Exam for M.Sc degree in Physics
2003 1st Rank amongst 45 Department Alumni in B.Sc.
1998 Silver Medalist of the 11th National Physics Olympiad

 

Relevant industry experience

2012   Recommendation System Development using Deep Machine Learning Technologies as a collaboration project from industry in Prof. Kollmann’s Lab, Heinrich Heine University, Düsseldorf

 

Publications

  • CaMuS: simultaneous fitting and de novo imputation of cancer mutational signature

    The identification of the mutational processes operating in tumour cells has implications for cancer diagnosis and therapy. These processes leave mutational patterns on the cancer genomes, which are referred to as mutational signatures. Recently, 81 mutational signatures have been inferred using…

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  • Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy

    Pleomorphic dermal sarcoma (PDS) is a rare malignant cutaneous tumor with an unknown cell of origin. Locally defined tumors can be treated by curative excisions, whereas advanced stages of the disease are difficult to treat, using standard regimens. We performed whole-exome sequencing on a cohort…

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  • Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels

    Tumour heterogeneity encompasses both the malignant cells and their microenvironment. While heterogeneity between individual patients is known to affect the efficacy of cancer therapy, most personalized treatment approaches do not account for intratumour heterogeneity. We addressed this issue by…

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  • Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies

    Genomic profiling revealed the identity of at least 5 subtypes of diffuse large B-cell lymphoma (DLBCL), including the MCD/C5 cluster characterized by aberrations in MYD88, BCL2, PRDM1, and/or SPIB. We generated mouse models harboring B cell–specific Prdm1 or Spib aberrations on the background of…

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