Research Area A
Mechanisms of B cell-specific signaling pathways in lymphomagenesis
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A01
Deciphering the role of oncogenic BTK mutations in DLBCL
Prof. Dr. med. Hans Christian Reinhardt, Dr. med. Sebastian Scheich -
A02
Targeting UBA6 signaling in B cell lymphoma
Prof. Dr. med. Thomas Oellerich, Dr. med. Ruth Fluemann -
A03
LUBAC and its enzymatic activities in the development and therapy of ABC-diffuse large B-cell lymphoma
Prof. Dr. rer. nat. Henning Walczak, Dr. rer. nat. Gianmaria Liccardi -
A04
Role of CASP8/cFLIP dimer in controlling lymphomagenesis
Prof. Dr. rer. nat. Hamid Kashkar, Dr. rer. nat. Alessandro Annibaldi -
A06
Understanding resistance towards BCL2-inhibition in CLL by exploring lytic and non-lytic mechanisms of programmed cell death
Dr. med. Lukas Frenzel, Dr. rer. nat. Melanie Fritsch
Research Area B
Understanding the molecular dialogues, cellular composition and plasticity of the lymphoma microenvironment
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B01
Dissecting the role of tyrosine kinases as key regulators and therapeutic targets in the microenvironment of chronic lymphocytic leukemia
Prof. Dr. med. Michael Hallek, Dr. med. Laura Beckmann -
B02
Temporal and spatial elucidation of NF- κB signaling in B cell lymphomagenesis
Prof. Dr. med. Christian Pallasch, Prof. Dr. rer. nat. Manolis Pasparakis -
B03
Targeting fumarate hydratase as metabolic gateway to ferroptosis sensitization
Prof. Dr. rer. nat. Silvia von Karstedt, Prof. Dr. rer. nat. Christian Frezza, Prof. Dr. med. Hans Christian Reinhardt -
B05
Combining TME modulating targeted therapies with new CAR-T cell strategies to improve CAR-T cell response in B cell lymphomas
Dr. rer. nat. Markus Chmielewski, Prof. Dr. med. Dr. nat. med. Roland Ullrich -
B06
Deciphering lymphoma microenvironment interactions for the development of multispecific antibody strategies
Dr. rer. nat. Phuong-Hien Nguyen, Prof. Dr. med. Dr. nat. med. Philipp Schommers
Research Area C
Understanding the profound genetic and phenotypic heterogeneity of lymphoma
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C01
The role of NLRC5 and additional genetic and microenvironmental factors in the pathogenesis and immunotherapeutic targeting of classic Hodgkin lymphoma
Prof. Dr. rer. nat. Ralf Küppers, Dr. rer. nat. Maria Cartolano -
C02
Functional Elucidation of highrisk Mantle Cell Lymphoma and CAR-T cell Therapy Resistance
Dr. med. Ron Jachimowicz, Dr. med. Stefan Alig, Prof. Dr. med. Thomas Oellerich -
C04
Modeling the clonal evolution of high-risk CLL
Prof. Dr. rer. nat. Martin Peifer, Dr. med. Kirsten Fischer -
C05
Characterization of Richter-transformed lymphoma and genomic instability as a potential vulnerability in 17p-deleted lymphomas
Prof. Dr. med. Björn Chapuy, Prof. Dr. med. Barbara Eichhorst -
C06
Artificial intelligence-assisted morphological profiling, risk stratification and classification of B cell malignancies
Prof. Dr. med. Dr. nat. med. Othman Al-Sawaf, Prof. Dr. rer. nat. Katarzyna Bozek
Z Projects
Central administrative project and program-specific projects: Integration and application of novel technologies and data management
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Z01
Central administration project
Prof. Dr. med. Michael Hallek -
Z02
Service project: Multiparametric analysis of lymphoma cells and their microenvironment
Prof. Dr. med. Thomas Oellerich, Dr. med. Lukas Frenzel, Prof. Dr. med. Dr. rer. nat. Michal Schweiger, Dr. rer. nat. Marie-Christine Albert, Dr. med. Lena Katharina Hieggelke -
Z03
Information infrastructure project (INF): Bioinformatics and Data management
Prof. Dr. rer. nat. Martin Peifer, Dr. rer. nat. Monica Valencia-Schneider, Dr. rer. nat. Nima Abedpour, Dr. rer. nat. Rahil Gholamipoorfard