Contact information
Institute for Cell-Biology (Oncological Research)
University Hospital Essen
Virchowstraße 173
45122 Essen
CV
Academic education
| 1989 - 1995 | PhD studies at the University of Cologne, Institute for Genetics, Department of Prof. K. Rajewsky |
| 1983 - 1989 | Study of Biology at the University of Cologne, Cologne, Germany |
Scientific degrees
| 2004 | Professor (C4) for Molecular Genetics, Institute for Cell Biology (Tumor Research), University Hospital Essen, University of Duisburg-Essen |
| 1999 | Habilitation in Genetics, University of Cologne |
| 1995 | Dr. rer. nat. (PhD), University of Cologne; Supervisor: Prof. K. Rajewsky (grade: summa cum laude) |
| 1989 | Diploma in Biology, University of Cologne |
Scientific career
| 2004 - present | Professor (C4) for Molecular Genetics, Institute for Cell Biology (Tumor Research), University Hospital Essen, University of Duisburg-Essen |
| 2000 - 2001 | Sabbatical (6 months) at the Institute for Cancer Genetics, Columbia University, New York, USA, Dept. of Prof. R. Dalla-Favera |
| 1999 - 2003 | Lecturer (Privatdozent) at the Institute for Genetics, University of Cologne |
| 1999 - 2003 | Heisenberg-Stipend of the German Research Council (Deutsche Forschungsgemeinschaft) |
| 1996 - 2002 | Postdoctoral fellow and group leader in a special research program (Sonderforschungsbereich) on Hodgkin's lymphoma, University of Cologne |
Honors/ Awards/ Memberships
| 2018 | Karl Musshoff Prize for Basic and Translational Science |
| 2016 | Jaap de Graeff Medal of the University of Leiden |
| 2013 - present | Associate Editor Leukemia |
| 2004 | Wilhelm-Warner-Prize for Cancer Research |
| 2004 | German Cancer Aid Prize (Deutscher Krebshilfepreis) 2001 (together with K. Rajewsky and M.-L. Hansmann) |
| 1999 | Heisenberg-Stipend of the German Research Council (DFG) |
| 1998 | Georges-Köhler-Prize of the German Society for Immunology |
| 1996 | PCR Award for young scientists (Boehringer Mannheim, 1996), 1st Prize |
Publications
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Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas
Histone methylation-modifiers, such as EZH2 and KMT2D, are recurrently altered in B-cell lymphomas. To comprehensively describe the landscape of alterations affecting genes encoding histone methylation-modifiers in lymphomagenesis we investigated whole genome and transcriptome data of 186 mature…
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Loss of function mutations of BCOR in classical Hodgkin lymphoma
BCOR is a component of a variant Polycomb repressive complex 1 (PRC1.1). PRC1 and PRC2 complexes together constitute a major gene regulatory system critical for appropriate cellular differentiation. The gene is upregulated in germinal center (GC) B cells and mutated in a number of hematologic…
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Impact of a faulty germinal center reaction on the pathogenesis of primary diffuse large B cell lymphoma of the central nervous system
Primary lymphoma of the central nervous system (PCNSL, CNS) is a specific diffuse large B cell lymphoma (DLBCL) entity confined to the CNS. Key to its pathogenesis is a failure of B cell differentiation and a lack of appropriate control at differentiation stages before entrance and within the…
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Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas
B cells have the unique property to somatically alter their immunoglobulin (IG) genes by V(D)J recombination, somatic hypermutation (SHM) and class-switch recombination (CSR). Aberrant targeting of these mechanisms is implicated in lymphomagenesis, but the mutational processes are poorly understood.…