Contact information

Prof. Dr. rer. nat. Ralf Küppers

Institute for Cell-Biology (Oncological Research)

University Hospital Essen

Virchowstraße 173

45122 Essen




Academic education

1989 - 1995 PhD studies at the University of Cologne, Institute for Genetics, Department of Prof. K. Rajewsky
1983 - 1989 Study of Biology at the University of Cologne, Cologne, Germany


Scientific degrees

2004 Professor (C4) for Molecular Genetics, Institute for Cell Biology (Tumor Research), University Hospital Essen, University of Duisburg-Essen
1999    Habilitation in Genetics, University of Cologne
1995 Dr. rer. nat. (PhD), University of Cologne; Supervisor: Prof. K. Rajewsky (grade: summa cum laude)
1989 Diploma in Biology, University of Cologne


Scientific career

2004 - present Professor (C4) for Molecular Genetics, Institute for Cell Biology (Tumor Research), University Hospital Essen, University of Duisburg-Essen
2000 - 2001 Sabbatical (6 months) at the Institute for Cancer Genetics, Columbia University, New York, USA, Dept. of Prof. R. Dalla-Favera
1999 - 2003 Lecturer (Privatdozent) at the Institute for Genetics, University of Cologne
1999 - 2003 Heisenberg-Stipend of the German Research Council (Deutsche Forschungsgemeinschaft)
1996 - 2002 Postdoctoral fellow and group leader in a special research program (Sonderforschungsbereich) on Hodgkin's lymphoma, University of Cologne


Honors/ Awards/ Memberships

2018 Karl Musshoff Prize for Basic and Translational Science
2016 Jaap de Graeff Medal of the University of Leiden
2013 - present Associate Editor Leukemia
2004 Wilhelm-Warner-Prize for Cancer Research
2004 German Cancer Aid Prize (Deutscher Krebshilfepreis) 2001 (together with K. Rajewsky and M.-L. Hansmann)
1999 Heisenberg-Stipend of the German Research Council (DFG)
1998 Georges-Köhler-Prize of the German Society for Immunology
1996 PCR Award for young scientists (Boehringer Mannheim, 1996), 1st Prize


  • Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas

    Histone methylation-modifiers, such as EZH2 and KMT2D, are recurrently altered in B-cell lymphomas. To comprehensively describe the landscape of alterations affecting genes encoding histone methylation-modifiers in lymphomagenesis we investigated whole genome and transcriptome data of 186 mature…

  • Loss of function mutations of BCOR in classical Hodgkin lymphoma

    BCOR is a component of a variant Polycomb repressive complex 1 (PRC1.1). PRC1 and PRC2 complexes together constitute a major gene regulatory system critical for appropriate cellular differentiation. The gene is upregulated in germinal center (GC) B cells and mutated in a number of hematologic…

  • Impact of a faulty germinal center reaction on the pathogenesis of primary diffuse large B cell lymphoma of the central nervous system

    Primary lymphoma of the central nervous system (PCNSL, CNS) is a specific diffuse large B cell lymphoma (DLBCL) entity confined to the CNS. Key to its pathogenesis is a failure of B cell differentiation and a lack of appropriate control at differentiation stages before entrance and within the…

  • Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas

    B cells have the unique property to somatically alter their immunoglobulin (IG) genes by V(D)J recombination, somatic hypermutation (SHM) and class-switch recombination (CSR). Aberrant targeting of these mechanisms is implicated in lymphomagenesis, but the mutational processes are poorly understood.…