Contact information
Department of Translational Genomics
CMMC - Center for Molecular Medicine Cologne
University of Cologne
Robert-Koch-Straße 21
50931 Cologne
University of Cologne
Weyertal 115b
50931 Cologne
Research Projects
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B02
Deciphering the role of BIRC3 in lymphomagenesis and resistance to therapy
Dr. rer. nat. Nieves Peltzer, Prof. Dr. med. Christian Pallasch -
Z02
Service project: Multiparametric analysis of lymphoma cells and their microenvironment
Prof. Dr. med. Reinhard Büttner, Prof. Dr. med. Thomas Oellerich, Dr. rer. nat. Nieves Peltzer, Dr. med. Lukas Frenzel, Prof. Dr. med. Dr. rer. nat. Michal Schweiger
CV
Scientific degrees
2007 - 2012 | PhD in Life Science, University of Lausanne, Switzerland |
2005 - 2007 | Master thesis (Research traineeship), La Plata University, Argentina and Institut Nationale de la Recherche Agronomique (INRA), Toulouse, France |
2000 - 2006 | Degree in Biotechnology, Quilmes University, Buenos Aires, Argentina |
Scientific career
2012 - present | Post-doctoral fellow at UCL Cancer Institute, London, UK |
2007 - 2012 | PhD student at the Physiology Department, University of Lausanne, Switzerland |
02/2007 - 08/2007 | Internship at Institut Nationale de la Recherch Agronomique (INRA), Toulouse, France |
2005 - 2007 | Intern and master student at Biochemistry and Molecular Biology Institute La Plata University, Buenos Aires, Argentina |
Service to the scientific community and honours
2015 - 2016 | Advanced Mobility Postdoc Fellowship awarded by the Swiss National Science Foundation (P300P3_158509) |
2013 - 2015 | Early Mobility Postdoc Fellowship awarded by the Swiss National Science Foundation (P2LAP3_148447) |
02/2007 - 08/2007 | ECOS-Sud fellowship. Financing Franco-Argentine internships |
Publications
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Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair
Cell death coordinates repair programs following pathogen attack and tissue injury. However, aberrant cell death can interfere with such programs and cause organ failure. Cellular FLICE-like inhibitory protein (cFLIP) is a crucial regulator of cell death and a substrate of Caspase-8. However, the…
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cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation
Cellular inhibitor of apoptosis proteins (cIAPs) are RING-containing E3 ubiquitin ligases that ubiquitylate receptor-interacting protein kinase 1 (RIPK1) to regulate TNF signalling. Here, we established mice simultaneously expressing enzymatically inactive cIAP1/2 variants, bearing mutations in the…
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CDK9 inhibition as an effective therapy for small cell lung cancer
Treatment-naïve small cell lung cancer (SCLC) is typically susceptible to standard-of-care chemotherapy consisting of cisplatin andetoposide recently combined with PD-L1 inhibitors. Yet, in most cases, SCLC patients develop resistance to first-line therapy andalternative therapies are urgently…
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Linear ubiquitin as a common regulator of cellular stress
Linear or M1-ubiquitination (Ub) is required for optimal NF-kB activation and for cell death inhibition. Using Drosophila as a model organism, Aalto et al. found that hypoxia, oxidative and mechanical stress induced M1-Ub by the HOIP homolog, LUBEL. Increased M1-Ub had a protective function driven…
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Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men
Aberrant cell death can cause inflammation and inflammation-related diseases. While the link between cell death and inflammation has been widely established in mouse models, evidence supporting a role for cell death in the onset of inflammatory and autoimmune diseases in patients is still missing.…
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RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation
Receptor-interacting protein kinase (RIPK) 1 functions as a key mediator of tissue homeostasis via formation of Caspase-8 activating ripoptosome complexes, positively and negatively regulating apoptosis, necroptosis, and inflammation. Here, we report an unanticipated cell-death- and…
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Cell Death and Inflammation - A Vital but Dangerous Liaison
The immune system has developed multiple ways to fight infection. Yet, it is constantly tasked with overcoming newly developing pathogenic mechanisms of resistance to host immunity. In most mammals, the stimulation of both innate and adaptive immune receptors can result in gene activation and cell…